#$%^&*AU2018211345B220191031.pdf#####Abstract The present invention includes a genetically-modified non-human animal model of longevity and increased health span, which is associated with 5 reduced tumorigenesis and tumor metastasis, as well as related methods for increasing longevity and health span, reducing tumorigenesis and tumor metastasis, and identifying active agents that confer increased longevity or health span, or reduced tumorigenesis or tumor metastasis. 10 15 20 25 30 35 92
