The present invention relates to an antibody specifically binding to a pancreatic adenocarcinoma upregulated factor (PAUF) protein and use thereof.The antibody of the present invention binds to a PAUF protein with high specificity and affinity and thereby inhibits the proliferation, migration, invasion, and in vivo growth, and thus the antibody of the present invention can be effectively used in the field of diagnosis and treatment of diseases such as cancer in which PAUF proteins are overexpressed.
