PROBLEM TO BE SOLVED: To provide novel molecular targets for drug screening assays used to identify compounds and binding peptides that inhibit MUC1-dependent tumorigenesis.SOLUTION: Cell proliferation associated with aberrant expression of MUC1 is particularly focused upon, and mechanisms associated with MUC1 cell proliferation are discussed. The invention provides polypeptide fragments of a Fas associated factor binding to a valosin-containing protein or a ubiquitinated protein.SELECTED DRAWING: Figure 1COPYRIGHT: (C)2016,JPO&INPIT【課題】MUC1-依存性腫瘍形成を阻害する化合物および結合性ペプチドを同定するために使用した薬剤スクリーニング分析法の新規な分子標的の提供。【解決手段】MUC1の異常な発現に関与する細胞増殖に特に焦点が当てられ、MUC1細胞増殖に関与する機構。ユビキチン化蛋白質、或いはバロシン含有蛋白質に結合するFas関連因子のポリペプチドフラグメント。【選択図】図1
