Light-mediated anti-cell proliferative compositions and methods

• 收藏
• 分享

专利权人:

Theresia A. Banks;Carl F Ware;Timothy C. Cheung

发明人:

Carl F Ware,Timothy C. Cheung,Theresia A. Banks

申请号：

US12446729

公开号：

US09694058B2

申请日:

2007.10.25

申请国别(地区):

US

年份:

2017

代理人:

摘要：

The tumor-necrosis factor superfamily member LIGHT (p30； TNFSF-14) is a cytokine for inducing immune responses against tumors. A novel biochemical approach is used to decorate the surface of tumor cells with LIGHT. LIGHT decorated cells can be used to vaccinate and induce effective, sustained immunity against cells expressing neo or pathogen associated antigens. Variants of LIGHT are described that enhance binding to cellular receptors (e.g., LT beta receptor) and decrease regulation by inhibitors (e.g., Decoy Receptor 3) increasing ability to stimulate immunity.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/