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IMMUNE CELL COMPOSITIONS AND METHODS OF USING SAME
专利权人:
MEMORIAL SLOAN KETTERING CANCER CENTER
发明人:
ADUSUMILLI, PRASAD S.
申请号:
CA3007980
公开号:
CA3007980A1
申请日:
2016.12.08
申请国别(地区):
CA
年份:
2017
代理人:
摘要:
Disclosed herein are cells that are immunoinhibitory cell, which cells recombinantly express a dominant negative form of an inhibitor of a cell-mediated immune response of the cell. In certain embodiments, the immunoinhibitory cell is a regulatory T cell. In another aspect, provided herein is a regulatory T cell that recombinantly expresses a dominant negative form of an inhibitor of a regulatory T cell-mediated immune response. The cells can be sensitized to an antigen that is the target of a pathologic immune response associated with an immune-mediated disorder. Additionally provided are methods of using such cells to treat an immune-mediated disorder in a subject in need thereof.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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