The present invention relates to a pharmaceutical composition comprising acebrophylline and having fast acting property and durability and, more specifically, to a sustained-release pharmaceutical composition comprising acebrophylline and a hydrophobic material. According to the present invention, the simple matrix type sustained-release medicine containing acebrophylline increases convenience of taking a medicine, thereby expecting significantly improved compliance of taking the medicine and treatment effect.본 발명은 아세브로필린을 포함하며 속효성과 지속성을 동시에 가지는 약학적 조성물에 관한 것이다. 보다 상세하게, 아세브로필린 및 소수성 서방성 기제를 포함하는 서방형 약학 조성물에 관한 것이다.