Vector expressing simultaneously 12-mer TRAIL and HSV-TK suicide gene, and anti-cancer stem cell therapeutic agent using the same

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专利权人:

ポステック アカデミー‐インダストリー ファウンデーション;ビオド シーオー．，エルティーディー．

发明人:

ヤング チュル スング,サエ ウオン キム,ス ジン キム,サング フーン パーク

申请号：

JP2016219322

公开号：

JP6552471B2

申请日:

2016.11.10

申请国别(地区):

JP

年份:

2019

代理人:

摘要：

The present invention relates to a DNA cassette comprising a nucleotide sequence encoding dodecameric TRAIL and a suicide gene nucleotide sequence, a recombinant expression vector comprising the DNA cassette, a recombinant adenovirus prepared by using the recombinant expression vector, a host cell transduced with the recombinant adenovirus, a composition for treating cancer comprising the host cell, and a method for treating cancer comprising the step of administering the composition for treating cancer to a subject. The stem cell therapy coexpressing dodecameric TRAIL and HSV-TK by introduction of the DNA cassette of the present invention has more excellent anticancer effects than the known therapy, and thus can be effectively used in the treatment of many different types of solid tumors and metastatic tumors.

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中国工程科技知识中心

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http://www.ckcest.cn/home/