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COMBINAISON DE SAPACITABINE (CNDAC) ET INHIBITEURS DE METHYLTRANSFERASE D'ADN COMME LA DECITABINE ET LA PROCAINE
专利权人:
CYCLACEL LIMITED
发明人:
GREEN, SIMON RICHARD,MACKAY, RUTH,FLEMING, IAN NEIL
申请号:
CA2725295
公开号:
CA2725295C
申请日:
2009.06.05
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
A first aspect of the invention relates to a combination comprising a DNAmethyltransferase inhibitor and 1-(2-C-cyano-2-dioxy-.beta.-D-arabino-pentofuranosyl)-N4- palmitoyl cytosine, or ametabolite thereof. A second aspect of the inventionrelates to a pharmaceutical product comprising a DNA methyltransferaseinhibitor and 1-(2-C-cyano-2-dioxy-.beta.-D-arabino-pentofuranosyl)-N4-palmitoyl cytosine, or a metabolite thereof, as a combinedpreparation for simultaneous, sequential or separate use intherapy. A third aspect of the invention relates to a method of treating aproliferative disorder, said method comprisingsimultaneously, sequentially or separately administering a DNAmethyltransferase inhibitor and 1-(2-C-cyano-2-dioxy-.beta.-D-arabino-pentofuranosyl)-N4-palmitoyl cytosine, or a metabolite thereof, to a subject.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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