Administration of nedd8-activating enzyme inhibitor and hypomethylating agent

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专利权人:

MILLENNIUM PHARMACEUTICALS INC.

发明人:

SMITH PETER G.

申请号：

NZ62488112

公开号：

NZ624881A

申请日:

2012.11.02

申请国别(地区):

NZ

年份:

2016

代理人:

摘要：

Provided is the use of a combination of a NAE inhibitor, preferably ((1S,2S,4R)-4-(4-((1S)-2,3-dihydro-1H-inden-1-ylamino)-7H-pyrrolo[2,3 d]pyrimidin 7-yl)-2-hydroxycyclopentyl)methyl sulfamate (MLN4924) or { (1S,2S,4R)-4-[(6-{ [(1R,2S)-5-chloro-2 methoxy-2,3-dihydro-1H-inden-1-yl]amino} pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl} -methyl sulfamate (I-216), and a hypomethylating agent, preferably azacitidine or decitabine, in the treatment of cancer.

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