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Combination of medicinal herbs, Kate, Carola Hersenide, used
专利权人:
BERLIN-CHEMIE AG
发明人:
申请号:
ARP180100556
公开号:
AR111265A1
申请日:
2018.03.09
申请国别(地区):
AR
年份:
2019
代理人:
摘要:
It is generally related to immunology and molecular biology. This document provides drug combinations including (a) antibodies.Or the binding part of their antigensFor Ly75,(b) The second anti-cancer entity;2. Nucleic acid encoded by combination of antibodies;2. The method of preparing antibody combination;And the treatment of diseases,For example, neutral cancer because of Ly75 performance or activity Requirement 1: Include (a) combination of anti-Ly75 antibodies.Or part of its antigenIt competes with an antibody that consists of a heavy chain variable region, including the amino acid sequence exposed in ID 1.It also includes a variable light chain region, including the amino acid sequence exposed in ID 2.Or anti-Ly75 antibodiesOr part of its antigenUnderstand this antibody: (a) a variable heavy chain region, including: (1) the first hexachlorobenzene composed of ID 5;(2) The second kind of hexachlorobenzene, including SEC ID No.6;(3) The third kind of hexachlorobenzene, including ID 7;(b) A light chain variable region, including: (1) the first VLCDR consisting of ID 8;(2) The second VLCDR, including SEC ID No.9;(3) The third VLCDR, including SEC ID 10;Alternative text: Any one or more of the above SEC forms an independent one.Two...Three...Four or five alternatives2. Amino acid addition or distribution;And (b) an anti-CD20 antibody or a part of the binding antigen,Understand this antibody: (a) a variable heavy chain region, including: (1) the first hexachlorobenzene composed of SEC number 40;(2) The second kind of hexachlorobenzene, including ID 41;(3) The third kind of hexachlorobenzene, including ID No. 42;(b) Light chain transformation region, including: (1) the first VLCDR, including SEC ID No. 43;(2) The second VLCDR includes ID No. 44;(3) The third VLCDR, including ID No. 45;Alternative text: Any one or more of the above SEC forms an independent one.Two...Three...Four or five alternatives2. Amino acid addition or distribution;Where the combination of drugs i
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