Ari Melnick,Leandro Carlos A. Cerchietti,Mariano G. Cardenas,Fengtian Xue,Alexander D. MacKerell
申请号：
US14899083
公开号：
US09943506B2
申请日:
2014.06.16
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention provides compositions and methods for blocking the BCL6 BTB domain with small molecule, non-peptide compounds as disclosed and claimed herein. BCL6 is a transcriptional repressor of the BTB-POZ (brie a brae, tramtrack, broad complex/pox virus zincfinger) family of proteins. It is required for normal development of germinal center (GC) B-cells and is also the most commonly involvedoncogene in diffuse large B-celllymphomas (DLBCLs), and constitutive expression of BCL6 in GC B-cells causes DLBCL in mice.
