Small molecules blocking histone reader domains

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专利权人:

Memorial Sloan-Kettering Cancer Center;University of Copenhagen

发明人:

Groth, Anja,Saredi, Giulia,Huang, Hongda,Hammond, Colin,Patel, Dinshaw

申请号：

AU2016332352

公开号：

AU2016332352A1

申请日:

2016.09.30

申请国别(地区):

AU

年份:

2018

代理人:

摘要：

The present invention relates to small molecules interfering with the conformational space of the TONSL ARD occupied by the histone H4 tail. These small molecules targets the binding pocket of TONSL encompassing the H4 residues K12- R23 and act by preventing or disrupting the binding of the H4 tail K12- R23 with the TONSL ARD via direct competition or via allosteric disruption of the binding pocket. The present inventors have identified and solved the structure of a histone reader domain of TONSL termed the ARD (ankyrin repeat domain).

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/