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LYOPHILIZED DRUG OF CYTOTOXIC DIPEPTIDES
专利权人:
ОНКОПЕПТАЙДС АБ (SE)
发明人:
СПИРА Як (SE),ЛЕМАНН Фредрик (SE)
申请号:
RU2013152751/15
公开号:
RU2013152751A
申请日:
2012.04.25
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A lyophilized pharmaceutical preparation comprising: (i) melphalan fluorophenamide or a pharmaceutically acceptable salt thereof and (ii) at least one excipient selected from the group consisting of polysorbate; polyethylene glycol; β-cyclodextrin; α-cyclodextrin; hydroxypropyl-β-cyclodextrin; sulfobutyl ether-β-cyclodextrin; lactose; benzyl alcohol; disodium succinate; propylene glycol; Cremophor EL; dimethyl sulfoxide; D-mannitol; Trehalose; Sucrose and amino acid. 2. The lyophilized pharmaceutical preparation of claim 1, wherein the excipient is selected from the group consisting of Polysorbate 80; PEG 400; lactose; benzyl alcohol; disodium succinate; propylene glycol; PEG 300; Cremophor EL; dimethyl sulfoxide; D-mannitol; Trehalose; Sucrose and histidine. 3. The lyophilized pharmaceutical preparation according to claim 1, wherein said melphalan fluorophenamide is melphalan fluorophenamide hydrochloride (J1). A lyophilized pharmaceutical preparation according to claim 1, wherein said at least one excipient has surfactant properties. A lyophilized pharmaceutical preparation according to claim 1, wherein said at least one excipient is polysorbate or polyethylene glycol. The lyophilized pharmaceutical preparation of claim 5, wherein said at least one excipient is Polysorbate 80.7. The lyophilized pharmaceutical preparation of claim 5, wherein said at least one excipient is PEG 400.8. The lyophilized pharmaceutical preparation according to claim 1, containing melphalan fluorophenamide hydrochloride (J1) and excipient Polysorbate 80.9. A lyophilized pharmaceutical preparation according to claim 1, comprising: (i) me�1. Лиофилизированный фармацевтический препарат, содержащий:(i) мелфалан фторфенамид или его фармацевтически приемлемую соль и(ii) по меньшей мере один эксципиент, выбранный из группы, включающей полисорбат; полиэтиленгликоль; β-циклодекстрин; α-циклодекстрин; гидроксипропил-β-циклодекстрин; сульфобутиловый эфир-β-циклодекстрин; лактозу; бензиловый спирт
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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