603751 Disclosed is a kit comprising separately a humanized anti-CD4 antibody capable of activating CD4+CD25+ regulatory T cells and methotrexate, wherein the humanized anti-CD4 antibody comprises an H chain V domain, an L chain V domain and an IgG 1 constant domain, and wherein: (a) the H chain V domain compnses the sequences DCRMY, VISVKSENYGANYAESVRG and SYYRYDVGAWFAY, and the L chain V domain comprises the sequences RASKSVSTSGYSYIY, LASILES and QHSRELPWT and/or (b) the H chain V domain has at least 80% sequence identity with SEQ ID No: 1 and the L chain V domain has at least 80% sequence identity with SEQ ID No: 2. Further disclosed is the therapeutic use of said combinations for treating rheumatic diseases such as rheumatoid arthritis.
