A method for guiding a therapy delivery device to a target tissue in a subject can include a step of providing a needle (12) having a main body that defines an inner lumen. An opening (26) can be located on a distal end portion of the main body. The opening can be in communication with the inner lumen. A ramp (32) can be positioned within the inner lumen and adjacent the opening. The ramp can be axially spaced apart from a distal end portion of the main body. The needle can be percutaneously inserted into the subject. The needle can be advanced to the target tissue. A camera (68) can be advanced through the inner lumen. The camera can be operated to visualize the target tissue. A therapy delivery device (70) can be advanced through the inner lumen. The therapy delivery device, under direct visualization, can be placed into communication with the target tissue.