As for this invention, the physiological coolant content composition of specification, for example section the cosmetics, in regard to the reinforcement in rest room tally or the medicine product which are applied the cooling effect, the cooling effect of the physiological coolant is reinforced here the substance by formula (i) or by adding the salt which that skin scientifically it can allow: R1 cr2 (OR3) co nr4 cr5r6 x or7 (i). The substance which is displayed by formula (i), as a physiological coolant itself without behaving, could bring the cooling effect which from the physiological coolant of low density is larger, because of this, feature mint like the menthol content product, it became possible to manufacture the composition where it is not the case that always it possesses the odor at the same time when/or the product which aroma is granted is produced, it was discovered that degree of freedom it is larger becomes possible.本発明は、特定の生理冷却剤含有組成物、例えば局所適用される化粧品、トイレタリーまたは医薬製品の冷却効果における増強に関し、ここで生理冷却剤の冷却効果は、式(I)による物質またはその皮膚科学的に許容し得る塩を加えることにより増強される:R1-CR2(OR3)-CO-NR4-CR5R6-X-OR7 (I)。式(I)により表される物質が、生理冷却剤自体として振舞わずに、低い濃度の生理冷却剤からより大きい冷却効果をもたらすことができ、これにより、メントール含有製品の特徴的なミント様臭気を必ずしも有するわけではない組成物を調製することが可能になり、かつ/または芳香を付与された製品を作製するにあたってのより大きい自由度が可能になることが見出された。
