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METHOD FOR INACTIVATING XENOANTIGENS IN BIOLOGICAL TISSUES
专利权人:
BIOCOMPATIBILITY INNOVATION S.R.L.
发明人:
Filippo NASO,Alessandro GANDAGLIA
申请号:
US15779953
公开号:
US20180353647A1
申请日:
2016.11.25
申请国别(地区):
US
年份:
2018
代理人:
摘要:
A method is for inactivating xenoantigens in biological tissues, particularly in tissues that can be used to manufacture bioprosthetic substitutes and/or in bioprosthetic substitutes that are already prepared and intended for human or veterinary clinical use. The method entails the following steps: providing a solution based on phenolic compounds, polyphenolic compounds or derivatives thereof, for the inactivation of at least part of the xenogeneic epitopes from such tissues; incubating the samples to be treated in the various solutions based on phenols/polyphenols in controlled conditions; and subjecting the treated tissues to a series of washes.
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