A multi-dose injection system (108) is disclosed that allows for safe and easy use of bulk containers, a multi-use tubing set (110), and syringes (86a, 86b) across multiple patients. The bulk containers may include a saline bottle (118) and a contrast bottle (120) for administration to a series of patients undergoing imaging procedures. The bottles (118, 120) may be fluidly connected to a cassette (114) that includes a saline valve (176) and a contrast valve (178) operable to control flow from the saline bottle (118) and the contrast bottle (120), respectively. The cassette (114) may be fluidly interconnected to the multi-use tubing set (110) that is, in turn, fluidly connected to syringes (86a, 86b) on a powerhead (50) and a patient-specific tubing set (112). The patient-specific tubing set (112) may be replaced between patients and may also serve to isolate the remainder of the multi-dose injection system (108) from contamination from bodily fluids.複数の患者にわたって、バルク容器、複数用途管類一式(110)、および注射器(86a、86b)の安全かつ容易な使用を可能にする複数用量注入システム(108)について開示される。バルク容器は、撮像手技を受ける一連の患者への投与のために、生理食塩水ボトル(118)と、造影剤ボトル(120)とを含んでもよい。ボトル(118、120)は、それぞれ、生理食塩水ボトル(118)および造影剤ボトル(120)からの流量を制御するように動作可能な生理食塩水弁(176)と、造影剤弁(178)とを含むカセット(114)に流体的に接続されてもよい。カセット(114)は、次に、パワーヘッド(50)および患者固有管類一式(112)上の注射器(86a、86b)に流体的に接続される複数用途管類一式(110)に流体的に相互接続されてもよい。