Adam Golebiowski;Jack A. Hunter;Jane Far-Jine Djung;Gary P. Schrum
发明人:
Jane Far-Jine Djung,Adam Golebiowski,Jack A. Hunter,Gary P. Schrum
申请号：
US12465704
公开号：
US08354407B2
申请日:
2009.05.14
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to 2-arylamino-4-(heterocyclic)aminopyrimidines inhibitors which are inhibitors and therefore inhibit Protein Kinase C-alpha (PKC-α). The PKC-α inhibitors of the present invention are important for improving myocardial intracellular calcium cycling, resulting in improved myocardial contraction and relaxation performance and thereby slowing the progression of heart failure. The present invention further relates to compositions comprising said 2-arylamino-4-(heterocyclic)amino-pyrimidines and to methods for controlling, abating, or otherwise slowing the progression of heart failure.
