In one aspect, the present invention is directed to a multi-lumen catheter with self-sealing hub and an attachable extension assembly. In a preferred aspect, the present invention can allows removal of the external fluid connections of an elongated percutaneous medical article, such as a catheter or cannula. The percutaneous medical article suitably contains a distal septum that prevents fluid movement within the intraluminal space of the percutaneous medical article, when the fluid connections are removed. A single-use, disposable extension set of one or more single lumen lines with associated clamp and cap is attached for intraluminal access and removed following clinical use. Retaining the catheter transition allows the catheter to be secured using methods common to the art.
