A device for treatment of a blood vessel includes: a catheter (C) configured to be inserted in a blood vessel (V) to be treated； a selection member (S) associated with the catheter (C) to prevent a blood flow at least in a determined section (T) of the blood vessel (V)； a self-perfusion lumen associated with the catheter (C) to provide a fluidic connection between a first portion (P1) of the blood vessel (V) upstream the determined section (T) and a second portion (P2) of the blood vessel (V) downstream the determined section (T)； a treatment system (F) associated with the catheter (C) to make a fluid drug flow at least to the determined section (T).
