COMPOSITION COMPRISING APPLE PEEL EXTRACT OF RUBIES AS EFFECTIVE COMPONENT FOR ANTIOXIDANT, ANTI-INFLAMMATORY, ANTI-DIABETIC, AND WHITENING EFFECTS, SKIN WRINKLE REDUCTION, OR GOUT INHIBITION
경북대학교 산학협력단;KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
CHO YOUNG JE,조영제,LEE EUN HO,이은호,KANG IN KYU,강인규
申请号：
KR1020180040159
公开号：
KR1020190117082A
申请日:
2018.04.06
申请国别(地区):
KR
年份:
2019
代理人:
摘要：
The present invention relates to a composition comprising an apple peel extract of Rubies (Malus pumila Mill.) as an effective component, for antioxidant, anti-inflammatory, anti-diabetic, and whitening effects, skin wrinkle reduction, and gout inhibition. In particular, the apple peel extract of Rubies, which is a newly-bred cultivar, according to the present invention, suppresses DPPH, ABTS, and TBARs radicals and increases PF, thereby exhibiting antioxidant effects； and inhibits tyrosinase and suppresses melanin production, thereby exhibiting skin-whitening effects. In addition, the composition inhibits elastase activity, thereby maintaining the molecular shape of elastin； inhibits collagenase activity, thereby exhibiting skin wrinkle-reducing effects； and inhibits hyaluronidase activity, thereby suppressing inflammations. In addition, the apple peel extract of Rubies exhibits an inhibitory effect on gout (arthritis) by inhibiting the activity of xanthin oxidase, and exhibits an inhibitory effect on type 2 diabetes by inhibiting the activities of &alpha；-amylase and &alpha；-glucosidase, and thus can be beneficially used as a pharmaceutical composition, a functional health food composition, a cosmetic composition, and the like.COPYRIGHT KIPO 2020본 발명은 루비에스 사과 껍질추출물을 유효성분으로 포함하는 항산화, 항염증, 항당뇨, 미백, 주름개선, 및 통풍 억제용 조성물에 관한 것으로, 본 발명의 신육성 품종인 루비에스(Rubies； Maluspumila Mill.) 사과 껍질추출물은 DPPH, ABTS, 및 TBARs 라디칼을 억제하고 PF를 증가시킴으로써 항산화 효과를 가지며, tyrosinase를 저해함으로써 melanin 생성을 억제하여 피부미백효과를 나타낸다. 또한, elastase 활성을 저해함으로써 elastin 분자 형태를 유지시키고, collagenase 활성을 저해함으로써 주름개선 효과를 나타내며, hyaluronidase 활성을 저해함으로써 염증반응을 억제시키는 효과가 있다. 뿐만 아니라, 루비에스 사과 껍질추출물은 xanthin oxidase 효소의 활성을 저해함으로써 통풍(관절염) 억제 효과를 나타내며, α-amylase와 α-glucosidase 효소활성을 저해함으로써 제2형 당뇨병 억제 효과를 나타내 약학적 조성물, 건강기능식품 조성물, 및 화장료 조성물 등으로 유용하게 이용될 수 있다.
