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Hepatitis C virus inhibitors
专利权人:
BRISTOL-MYERS SQUIBB COMPANY
发明人:
LAVOIE, RICO,BENDER, JOHN A.,YANG, ZHONG,BELEMA, MAKONEN,LOPEZ, OMAR D.,CHEN, QI,WANG, GAN,HEWAWASAM, PIYASENA
申请号:
PE2012000637
公开号:
PE20121354A1
申请日:
2010.11.05
申请国别(地区):
PE
年份:
2012
代理人:
摘要:
It refers to a different formula compound (I), where x and X 'are ch, CR1 or n respectively; E and' are ch, CR2 or n respectively, where R1 and R2 are formula compound (a),(b)Among them, R3 is h, CN or halogen; R4 is h, asphalt, etc.; R5 is H-C (or) R6, wherein R6 is alcoxi, asphalt, arilalcoxi, cycloquilo, etc. The most popular compounds are: (2,7-benzodiol (1h-benzodiazepine-5,2-diil (2S) - 2,1-pyridinediol ((1R) - 2-oxo-1-phenyl-2,1-ethane)), dimethyl dicarboxylate; (1s, 2R) - 2-methyl-1 - ((1R, 3S, 5R) - 3 - (4 - (1R, 3S -) (1R, 3S -) 5 (R) - 2 - (n - (methoxicarbonil) - o-meth-l-treonil) - 2-azabcyclo [3.1.0] hex-3-il) - 1h-imidazol-4-il (phenyl) - 2-naftil) - 1h-imidazol-2-il) - 2-azabicycleo [3.1.0] hex-2-il (carbon) prop IL;(1R) - 2 - ((2S) - 2 - (5 - (2 - ((2S) - 1 - ((2R) - 2 - (dimethylamine) - 2-phenyl-phenyl-di -) - 2-pyridine-2-pyridine-1-benzodiazo-1-benzodiazo-1-pyridine-1-benzodiol, among others. He also mentioned a pharmaceutical composer These compounds are inhibitors of NS5A protein encoded by hepatitis C virus and are useful in the treatment of hepatitis C.SE REFIERE A COMPUESTOS HETEROCICLICOS DE FORMULA (I) DONDE X Y X' SON CADA UNO CH, CR1 O N; Y E Y' SON CADA UNO CH, CR2 O N, DONDE R1 Y R2 SON CADA UNO COMPUESTOS DE FORMULA (a), (b), ENTRE OTROS, EN DONDE R3 ES H, CN O HALO; R4 ES H, ALQUILO, ENTRE OTROS; R5 ES H O -C(O)R6, EN DONDE R6 ES ALCOXI, ALQUILO, ARILALCOXI, CICLOALQUILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (2,7-NAFTALENDIILBIS(1H-BENCIMIDAZOL-5,2-DIIL(2S)-2,1-PIRROLIDINADIIL((1R)-2-OXO-1-FENIL-2,1-ETANODIIL)))BISCARBAMATO DE DIMETILO; ((1S,2R)-2-METOXI-1-(((1R,3S,5R)-3-(4-(6-(4-(2-((1R,3S,5R)-2-(N-(METOXICARBONIL)-O-METIL-L-TREONIL)-2-AZABICICLO[3.1.0]HEX-3-IL)-1H-IMIDAZOL-4-IL)FENIL)-2-NAFTIL)-1H-IMIDAZOL-2-IL)-2-AZABICICLO[3.1.0]HEX-2-IL)CARBONIL)PROPIL)CARBAMATO DE METILO; (1R)-2-((2S)-2-(5-(6-(2-(2-((2S)-1-((2R)-2-(DIMETILAMINO)-2-FENILACETIL)-2-PIRROLIDINIL)-1H-BENCIMIDAZOL-6-IL)-2-NAFTIL)-1H-BENCIMIDAZOL-2-IL)-1-PIRROLIDI
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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