EIF4A-抑制化合物及其相關方法农业专利-农业学术服务平台

发明人:: ERNST, JUSTIN T.,恩斯特　贾斯汀,恩斯特　賈斯汀,REICH, SIEGFRIED H.,瑞区　席格弗里德,瑞區　席格弗里德,SPRENGELER, PAUL A.,斯潘格勒　保罗,斯潘格勒　保羅,TRAN, CHINH,珍　钦,珍　欽,PACKARD, GARRICK KENNETH,帕卡得　嘉瑞克,XIANG, ALAN XIN,向　新,NILEWSKI,恩斯特贾斯汀,恩斯特賈斯汀,瑞区席格弗里德,瑞區席格弗里德,斯潘格勒保罗,斯潘格勒保羅,珍钦,珍欽,帕卡得嘉瑞克,向新

摘要：: The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof.For Formula I compounds X, Y, R1, R2, R3a, R3b, R4a, R4b and R5 are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4A and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.本發明係提供式I化合物或其立體異構物、互變異構物或醫藥上可接受鹽之合成、醫藥上可接受調配物及用途。就式I化合物，X、Y、R1、R2、R3a、R3b、R4a、R4b和R5係如說明書中所定義。本發明之式I化合物為eIF4A之抑制劑且可用於許多治療應用，包括(但不限於)治療發炎和各種癌症。