Methods of expanding tumor infiltrating lymphocytes (TILs), including peripheral blood lymphocytes and marrow infiltrating lymphocytes, from blood and/or bone marrow of patients with hematological malignancies, such as liquid tumors, including lymphomas and leukemias, and uses of such expanded TILs in the treatment of diseases such as cancers and hematological malignancies are disclosed herein.L'invention concerne des procédés d'expansion de lymphocytes infiltrant des tumeurs (TIL), notamment des lymphocytes du sang périphérique (PBL) et des lymphocytes infiltrant la moelle, à partir du sang et/ou de la moelle osseuse de patients atteints d'hémopathies malignes, telles que des tumeurs liquides, y compris des lymphomes et des leucémies, et des utilisations de tels TIL expansés dans le traitement de maladies telles que des cancers et des hémopathies malignes.