According to one embodiment, there is provided an anti-vibration structure for a handle of a portable brush cutter, the structure including: a pole (2); an operation unit (3) provided at a front portion of the pole (2); an engine (1) provided and a lever device (4) provided at a base portion of the pole (2); an attachment stay unit (10) fixed to a middle portion of the pole (2), the attachment stay unit (10) having an accommodation recess (20) at each end thereof; an operation handle (5) having a protrusion (27) protruding from each end thereof; and anti-vibration materials (18) sandwiched between the attachment stay unit (10) and a handle main body (22) in a left-right direction of the pole (2), so that one side of the anti-vibration material (18) is accommodated in the accommodation recess (20) while the protrusion (27) is inserted in an open-groove (32) formed on the other side of the anti-vibration material (18).