Combined administration of a hypoxia-activated prodrug, such as TH-302, a taxane, such as nab-paclitaxel, and a nucleoside analog chemotherapeutic, such as gemcitabine, are efficacious in the treatment of cancer, including pancreatic cancer.L'invention concerne l'administration combinée d'un promédicament activé par l'hypoxie, et d'un médicament chimiothérapeutique analogue d'un nucléoside, tel que la gemcitabin, laquelle administration combinée est efficace pour traiter le cancer, en particulier le cancer du pancréas.