JUNG, SUNG YOUB,CHOI, IN YOUNG,PARK, YOUNG JIN,KIM, JUNG KUK
申请号：
ARP170101804
公开号：
AR108969A1
申请日:
2017.06.29
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
Claim 1: a Pharmaceutical composition for preventing or treating congenital hyperinsulinism, which comprises the sequence of amino acids of the General formula (1): x¹ X - - - - - qgtf x⁷ SD x¹⁰ - S - - - x¹⁴ x¹² x¹³X¹⁵ x¹⁶ x¹⁷ - - - - - - - x¹⁸ x¹⁹ x²⁰ x²¹ - F - x²³ x²⁴ W - L - - - - - - x²⁷ x²⁸ x²⁹ x³⁰ (General formula (1), SEQ ID no. 45), of the General formula (1), x¹ is histidine (H) - histidilo Stimate N - dimethyl - histidilo,(b imidazopropionilo imidazoacetilo 4 - hydroxy, carboxy, B - (W), imidazopropionilo, tryptophan or tyrosine (y) or is absent X is acid methyl aminoisobutírico glutamic acid (AIB), D - alanineGlycine (g), SAR (n-metilglicine), Serine (S), or D - Serine, threonine (T), is x⁷ Valine (V)Cysteine or (c) x¹⁰ is tyrosine (y) or (c) x¹² is cysteine cysteine or lysine (k) (c) x¹³ is tyrosine (y) or cysteine (c) x¹⁴ is Leucine (L) or (c) x¹⁵ is cysteine Aspartic acid (d),Glutamic acid and cysteine), or (c) (e) x¹⁶ is glutamic acid, Aspartic acid (d), Serine (S), methyl - glutamic acid, cysteine, or (c) or absent x¹⁷ is Aspartic acid (d), glutamine (q),Glutamic acid (e), Lysine (k) Arginine (R), Serine (S), cysteine (c) or Valine (V), or absent x¹⁸ is alanine, Aspartic acid, glutamic acid (d), (e), arginine (R) Valine (V)(c) or cysteine, or absent x¹⁹ is alanine, arginine (R), Serine (S), Valine (V) or (c), cysteine, or absent x²⁰ is lysine (k), histidine (H), glutamine (q), Aspartic acid (d),Arginine (R) - methyl - glutamic acid, cysteine, or (c) or absent x²¹ is Aspartic acid glutamic acid (d), (e), Leucine (L), Valine (V) or (c), cysteine, or absent x²³ is isoleucine (i)(V) or Valine, arginine (R), or absent x²⁴ is Valine (V), arginine (R), alanine, cysteine, glutamic acid (c), (e), Lysine (k), glutamine (q), glutamic acid to methyl - or Leucine (L),Or is absent (i) is x²⁷ isoleucine, Valine (V), alanine (a), Lysine (k), (m), methionine, arginine or glutamine (q) (R), or absent x²⁸ is glutamine (q), Lysine (k), asparagine (n),Or Arginine (R), o
