新的抑制劑

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专利权人:

PROBIODRUG AG

发明人:

HEISER, Ulrich U,BUCHHOLZ, Mirko M,SOMMER, Robert R,DEMUTH, Hans-Ulrich H-U,MEYER, Antje A,.海澤,.布赫霍爾茨,.佐默,.德穆特,.邁耶

申请号：

HK16104524.9

公开号：

HK1216531A

申请日:

2016.04.20

申请国别(地区):

HK

年份:

2016

代理人:

摘要：

The invention relates to a compound of formula (I) or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof, wherein R1, R2, R3, R4 and R5 are as defined herein, as inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of N-terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*) under liberation of ammonia and the intramolecular cyclization of N-terminal glutamate residues into pyroglutamic acid under liberation of water.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/