OBSHCHESTVO S OGRANICHENNOY OTVETSTVENNOSTYU "VIK - ZDOROVYE ZHIVOTNYKH"
发明人:
VIOLIN, Boris Viktorovich,SEMENOV, Sergey Vyacheslavovich,PRISTENSKIY, Dmitriy Vladimirovich,ANISKOV, Aleksandr Andreevich
申请号：
MX2014011345
公开号：
MX361596B
申请日:
2013.06.06
申请国别(地区):
MX
年份:
2018
代理人:
摘要：
The invention relates to the field of veterinary science and medicine and can be used for the prophylaxis and treatment of bacterial infections. The aim of the present invention is to design a preparation based on azithromycin in the form of a solution, having a wide spectrum of antimicrobial activity, and in the form of an injection solution ready for use not only for introduction intravenously, but also for intramuscular, subcutaneous, intrauterine and intracisternal introduction. The antibacterial pharmaceutical composition comprises azithromycin, solvents and/or cosolvents, a preservative, and an antioxidant. The antioxidant is in the form of ascorbic acid or sodium ascorbate or calcium ascorbate or palmitoyl ascorbate or 4-methyl-2,6-di-tert-butylphenol or tert-butylhydroquinone, 2,4,5-trihydroxy-butyrophenone or sodium metabisulfite or alpha-tocopherol or thioglycerine or combinations thereof, whereas the preservative is in the form of benzyl alcohol, parabens, chloretone or combinations thereof with the following ratios of components by percentage mass: 5-50% azithromycin, 0.1-0.2% antioxidant, 1-2% preservative, the remainder being solvents.La invención se relaciona con la veterinaria y la medicina y se puede utilizar para la profilaxis y tratamiento de infecciones bacterianas. La composición farmacéutica inyectable antibacteriana comprende azitromicina, disolventes y/o codisolventes, un conservante y un antioxidante. El ácido ascórbico o ascorbato de sodio o ascorbato de calcio o ascorbato de palmitilo o 4-metil-2, 6-di-terc-butilfenol o terc-butilhidroquinona, 2,4,5- trihidroxi-butirofenona o metabisulfito de sodio o atocoferol o tioglicerin o combinaciones de los mismos pueden ser utilizados como el antioxidante, mientras que el alcohol bencílico, parabenos, cloretona, o combinaciones de los mismos se pueden usar como el conservante, disolventes orgánicos (dimetilacetamida o dimetilsulfóxido o N-metil-2-pirrolidona o 2-pirrolidona, o combinaciones de los
