Bis(arylmethylidene)acetone compound, anti-cancer agent, carcinogenesis-preventive agent, inhibitor of expression of Ki-Ras, ErbB2, c-Myc and Cycline D1, β-catenin-degrading agent, and p53 expression enhancer

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专利权人:

Hiroyuki Shibata

发明人:

Hiroyuki Shibata,Yoshiharu Iwabuchi,Hisatsugu Ohori,Hiroyuki Yamakoshi,Yuichi Kakudo

申请号：

US11993840

公开号：

US08178727B2

申请日:

2006.06.27

申请国别(地区):

US

年份:

2012

代理人:

摘要：

It has been demanded to improve the poor solubility of curcumin to develop an anti-tumor compound capable of inhibiting the growth of various cancer cells at a low concentration. Thus, disclosed is a novel synthetic compound, a bis(arylmethylidene)acetone, which has both of an excellent anti-tumor activity and a chemo-preventive activity. A bis(arylmethylidene)acetone (i.e., a derivative having a curcumin skeleton) which is an anti-tumor compound and has a chemo-preventive activity is synthesized and screened. A derivative having enhanced anti-tumor activity and chemo-preventive activity can be synthesized.

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