The present disclosure provides mutant immunomodulatory polypeptides and fusion polypeptides that include mutant immunomodulatory peptides. The present disclosure provides T cell regulatory multimeric polypeptides, and compositions comprising T cell regulatory multimeric polypeptides, wherein the T cell regulatory multimeric polypeptides include the mutant immunomodulatory polypeptides of the present disclosure. The present disclosure provides a nucleic acid comprising a nucleotide sequence encoding a T cell regulatory multimeric polypeptide, and a host cell comprising the nucleic acid. The present disclosure provides a method of modulating the activity of T cells, which method comprises contacting a T cell with a T cell regulatory multimeric polypeptide of the present disclosure.本開示は、変異免疫調節ポリペプチド、及び変異免疫調節ペプチドを含む融合ポリペプチドを提供する。本開示は、Ｔ細胞調節多量体ポリペプチド、及びＴ細胞調節多量体ポリペプチドを含む組成物を提供し、Ｔ細胞調節多量体ポリペプチドは、本開示の変異免疫調節ポリペプチドを含む。本開示は、Ｔ細胞調節多量体ポリペプチドをコードするヌクレオチド配列を含む核酸、及び核酸を含む宿主細胞を提供する。本開示は、Ｔ細胞の活性の調節方法を提供し、本方法は、Ｔ細胞と、本開示のＴ細胞調節多量体ポリペプチドとの接触を含む。
