GARRETT-THOMSON, Sarah, C.,ALMO, Steven, C.,SEIDEL, Ronald, D.
申请号：
EP17800069
公开号：
EP3458095A4
申请日:
2017.05.17
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
The present disclosure provides variant PD-L1 immunomodulatory polypeptides, and fusion polypeptides comprising the variant immunomodulatory peptides. The present disclosure provides T-cell modulatory multimeric polypeptides, and compositions comprising same, where the T-cell modulatory multimeric polypeptides comprise a variant immunomodulatory polypeptide of the present disclosure. The present disclosure provides nucleic acids comprising nucleotide sequences encoding the T-cell modulatory multimeric polypeptides, and host cells comprising the nucleic acids. The present disclosure provides methods of modulating the activity of a T cell； the methods comprise contacting the T cell with a T-cell modulatory multimeric polypeptide of the present disclosure.
