MIOZZI, MICHELE,ROUSE, TIMOTHY J.,NALL, BARRY E,DA VANZO, STEPHEN P.
申请号：
ARP170100160
公开号：
AR107406A1
申请日:
2017.01.20
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
2. The process of extracting crystalline particulate material from glycerine salt by the method of hydrodynamic cavitation. The resulting drug particles are physically stable compared to polymerization and / or polymerization during storage. 1. Characteristic 1: a method of making microcrystalline particles for glycerine salt acceptable to the drug, which is characterized by the following steps: (a) in the first room of the controlled hydrodynamic cave device；1. Mix the f83211 current of a solution, which contains a glycerine salt with acceptable efficacy and one or more surfactants dissolved in a solvent composed of 1-butanediol, 2-propanol and their mixture with ethanol； a. It contains one or more f832222 disease resistant liquid flows selected from a group of substances composed of diethyl ether, n-heptone, methyl tributyl ether and their mixtures； (b) f83212 and f8322 are mixed in the local confined flow to form a fluid activated cave with controlled flow； 1. Initiation of nucleation and direct production of nanocrystals in glycerine salts；(c) Transfer the mixed air flow to the second layer of the cave device controlling the flow and continue processing for 10 milliseconds or less； (d) The resulting flow is collected in a receiver containing a mixture of n-propane and MTBE in a volume ratio between 10:90 and 40:60 so that it can be assembled； (E) dried to form particles to cure； (f) removed surfactants； and (g) re dried to produce microparticles. Requirement 3: procedure according to requirement 1 or 2,characterized in that the surfactant is selected from the group consisting of lecithin, non-ionic surfactants such as Tween® or Span®,Sugar based surfactants, such as sucrose stearate or sucrose hexane, Requirements 8: a contained formula, Characts including microbic particles from a medical acceptable of glicoprodence Sal from a process from any requirements 1-6, Requirements 9: a pressure physical activity inhaler (PMDL), which is characterized by its full descr
