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NOUVEAU DÉRIVÉ DE GLUCOSE, ET PROCÉDÉ D'IMAGERIE DE CELLULE ET AGENT D'IMAGERIE UTILISANT LEDIT DÉRIVÉ
专利权人:
Hirosaki University
发明人:
申请号:
EP15776849.0
公开号:
EP3130596A1
申请日:
2015.04.06
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
A purpose of the present invention is to provide a novel glucose derivative, which is taken into cells via a membrane sugar transport system and is represented by formula (1). Another purpose of the present invention is to provide an imaging agent and an imaging method for a cell or intracellular molecule using said glucose derivative. Yet another purpose of the present invention is to provide a method for detecting cancer cells with good accuracy using said glucose derivative and an imaging agent to be used in said method. The present invention provides D-glucose derivatives and L-glucose derivatives in which glucose is bound to the 7-position of a fluorescent molecular group with a coumarin backbone or a quinolone backbone. Also provided are a cell imaging agent and imaging method using the derivative. A cancer cell imaging agent and imaging method using the L-glucose derivative is also provided. G is a group selected from formulas (G1) - (G4) below.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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