OULMASSOV TIM N.,MCBRIDE KEVIN E.,MILLER PAULA C.,ANDERSON JOHN C.,CROSSLAND LYLE D.,ADAMS THOMAS H.,QUROLLO BARBARA A.,GAVRIAS VICTORIA
申请号：
US20050145451
公开号：
US7202085(B2)
申请日:
2005.06.03
申请国别(地区):
美国
年份:
2007
代理人:
摘要：
DNA constructs and other compositions and methods for controlling gene expression in eukaryotic cells and organisms are derived from bacterial quorum sensing systems. One or more cis elements from the luxI promoter ("lux box") or a functionally similar sequence are incorporated in a eukaryotic promoter. A receptor protein from the LuxR family of transcriptional regulators, upon binding an acylated homoserine lactone (AHL) compound, interacts with the lux box, modulating the activity of the promoter.
