ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ БЮДЖЕТНОЕ УЧРЕЖДЕНИЕ "НАУЧНО-ИССЛЕДОВАТЕЛЬСКИЙ ИНСТИТУТ МЕДИЦИНЫ ТРУДА" РОССИЙСКОЙ АКАДЕМИИ МЕДИЦИНСКИХ НАУК (ФГБУ "НИИ МТ" РАМН)
发明人:
Кузьмина, Людмила Павловна,Коляскина, Мария Михайловна,Елов, Андрей Александрович,Помыканова, Юлия Сергеевна,Санин, Владислав Юрьевич,Хотулева, Анастасия Григорьевна,Ненашева, Раиса Анатольевна,Лазара
申请号：
EA201400780
公开号：
EA201400780A1
申请日:
2014.07.24
申请国别(地区):
EA
年份:
2016
代理人:
摘要：
the invention relates to medicine and can be used for determining the risk of development of fibrotic changes in the lung and liver.the present invention is to simplify the way of determining the risk of development and prediction of fibrotic changes in the lung and liver, and improving a great and its reliability in the clinical examinations and periodic medical examinations of workers in hazardous and \/ or hazardous conditions of work but for short (short) period of time.this goal is achieved, in a method of determining the risk of development of fibrotic changes in the lung and liver, which included the provision of venous blood in the genetic material, conducting with an r.l.f.t.... with special \u043f\u0440\u0430\u0439\u043c\u0435\u0440\u0430\u043c\u0438, definition of \u043d\u0443\u043a\u043b\u0435\u043e\u0442\u0438\u0434\u043d\u043e\u0439 sequence and on the basis of the definition of z - and s - gene mutations \u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0430\u0437 a1 - inhibitor.the study of the total dna in human blood, when cooking \u0430\u043c\u043f\u043b\u0438\u0444\u0438\u043a\u0430\u0446\u0438\u043e\u043d\u043d\u043e\u0439 mixture using specific probes \u043f\u0440\u0430\u0439\u043c\u0435\u0440\u044b with type TaqMan who served the point z and s gene mutations \u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0430\u0437 a1 - inhibitor in the middle, to determine the presence or absence of the human genome s - and z - a1 - inhibitor gene mutations in a \u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0430\u0437 \u0437\u0438\u0433\u043e\u0442\u043d\u043e\u043c, and \u0433\u0435\u0442\u0435\u0440\u043e\u0437\u0438\u0433\u043e\u0442\u043d\u043e\u043c versionin the absence of mutation of nucleotide links to s - and z - \u0430\u043b\u043b\u0435\u043b\u044f\u043c risk of development of fibrotic changes in the lung and the liver is less than 20%, in the presence of a gay \u0442\u0435\u0440\u043e\u0437\u0438\u0433\u043e\u0442\u043d\u043e\u0439 mutation in the s the risk
