A patient positioning device provided to position, protect and secure a patient on a support surface for transfer to another support surface or for preparation for surgery. The positioning device includes a sheet with a first and second flexible substrate coupled to the sheets top surface. The first and second flexible substrates may be padded. These substrates are capable of wrapping around an adjacent arm of the patient creating a wrapped engagement. This wrapped engagement may pad, protect, secure and elevate the arms from injury caused by pressure imparted thereon during surgery or transport. This positioning device may be lifted or slid from one support surface to another. Optionally, a third and fourth flexible substrate capable of wrapping around an adjacent arm of the patient creating a second wrapped engagement may be used for additional securing. Optionally, an inflatable support may be used with the device to aid when sliding or translating the device 10 with the patient thereon.