PROBLEM TO BE SOLVED: To provide a pre-filled syringe with bypass, the syringe that prevents excessive ejection of liquid and liquid leakage when mixing and dissolving a medicine with a medical fluid.SOLUTION: A pre-filled syringe of the present invention is provided in which a front chamber 6 and a rear chamber 7 for containing a first component and a second component are formed in a cylindrical main body 1, respectively, the front chamber 6 and the rear chamber 7 are partitioned by a stopper 3 inserted in the main body 1 and being flexibly pressed and contacted to an inner circumferential surface and forming multiple ribs R in the circumferential direction, and a bypass 13 for bringing the rear chamber 7 into communication with the front chamber 6 in the passage of the stopper 3 is recessed in the inner circumferential surface of the main body 1. The rib R includes a standard rib R1 with an outer diameter D1 more than an inner diameter D0 of the main body 1 in a front side outer circumference other than the rear end of the stopper 3, and an end rib R2 formed in an outer diameter D2 being not less than the inner diameter D0 and less than the outer diameter D1 of the standard rib R1 and for use in releasing high pressure in the rear end outer circumference of the stopper 3.SELECTED DRAWING: Figure 3COPYRIGHT: (C)2018,JPO&INPIT【課題】バイパス付プレフィルドシリンジの薬剤と薬液の混合溶解時の液の過剰な噴出及び液漏れを防止する。【解決手段】この発明は、筒状の本体1内に第1成分と第2成分をそれぞれ収容する前室6と後室7を形成し、該前室6と後室7は本体1内に挿入され、その内周面に弾力的に押接されて周方向の複数条のリブRを形成した栓体3によって仕切られ、上記本体1の内周面には上記栓体3の通過時に前室6と後室7を連通させるバイパス13を凹設したプレフィルドシリンジにおいて、上記リブRが前記栓体3の後端以外の前側外周に本体1の内径D0を越える外径D1を備えた標準リブR1と、栓体3の後端外周に上記内径D0以上であって標準リブR1の外径D1未満の外径D2に形成された高圧解放用の端部リブR2とを備えてなることを特徴としている。【選択図】図3