Kazuyuki Takahashi;Paul O. Zamora;Louis A. Pena;Xinhua Lin
发明人:
Kazuyuki Takahashi,Paul O. Zamora,Louis A. Pena,Xinhua Lin
申请号：
US12786256
公开号：
US08101570B2
申请日:
2010.05.24
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A heparin-binding growth factor (HBGF) analog having two substantially similar sequences (homodimeric sequences) branched from a single amino acid residue, where the sequences are analogs of a particular HBGF that binds to a heparin-binding growth factor receptor (HBGFR), or alternatively that bind to a HBGFR without being an analog of any particular HBGF. The homodimeric sequences may be derived from any portion of a HBGF. The synthetic HBGF analog may be an analog of a hormone, a cytokine, a lymphokine, a chemokine or an interleukin, and may bind to any HBGFR. Further provided are preparations for medical devices, pharmaceutical compositions and methods of using the same.
