Systems and methods are disclosed for transporting a transport target across a membrane that is impermeable or semi-permeable to the transport target via artificially created microchannels or through hypodermic microneedles. The transport target can be a medicant and the membrane can be a stratum corneum layer of skin. The transport is enhanced by the application of ultrasound energy having a high peak intensity, which generates an inertial cavitation effect, an acoustic streaming effect, or both.
