Peptidomimetic inhibitors of PSMA,compounds comprising them, and methods of use

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专利权人:

Cancer Targeted Technology LLC

发明人:

Berkman, Cliff

申请号：

AU2007226542

公开号：

AU2007226542B2

申请日:

2007.03.14

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

Compounds of the formula, A-L-B, wherein A is glutamate or a glutamate analog； L is a phosphoramidate or a phosphoramidate analog； and B is serine or a serine analog are described which are potent inhibitors of prostate-specific membrane antigen (PMSA). Such compounds are useful in treatment of prostate cancer； and when chemically attached to a fluorescent dye, can efficiently and selectively label prostate cancer cells for fluorescent imaging.

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