BARNETT, RICHARD S.,TIAN, FENG,PUTNAM, ANNA-MARIA A. HAYS,GYMNOPOULOS, MARCO,KNUDSEN, NICK,BECK, ANDREW,SUN, YING
申请号：
CA2874854
公开号：
CA2874854A1
申请日:
2013.06.07
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
This invention relates to prostate-specific membrane antigen (PSMA) antibodies and antibody drug conjugates comprising at least one non-naturally-encoded amino acid. Disclosed herein are aPSMA antibodies with one or more non-naturally encoded amino acids and further disclosed are antibody drug conjugates wherein the aPSMA antibodies of the invention are conjugated to one or more toxins. Also disclosed herein are non-natural amino acid dolastatin analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Typically, the modified dolastatin analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid antibody drug conjugates, dolastatin analogs, and modified non-natural amino acid dolastatin analogs, including therapeutic, diagnostic, and other biotechnology uses.
