Sustained release hepatocyte growth factor (HGF) hydrogel composition comprises a hydrogel prepared by crosslinking acidic gelatin obtained by alkali-hydrolysis of collagen, having a molecular weight of 100000-200000 Da determined by SDS-Page, having an isoelectric point of 5 and having a zeta potential in aqueous solution of -15 to -20 mV. Independent claims are also included for the following: (1) an agent comprising HGF dissolved in gelatin having the above properties, and (2) angiogenesis promoters comprising the above compositions. ACTIVITY : Antiarteriosclerotic Antianginal Vasotropic Antiangiogenetic. MECHANISM OF ACTION : None given in the source material.
