A canine hepatocyte growth factor gene and a 15 base pairs-deleted caninehepatocyte growth factor gene. These genes encode the following protein (a) or(b):(a) a protein having an amino acid sequence shown in SEQ ID NO: 2 or 4； and(b) a protein having an amino acid sequence comprising a deletion,substitution oraddition of one or several amino acids with respect to the amino acid sequenceshown inSEQ ID NO: 2 or 4, and having a canine hepatocyte growth factor activity.The canine hepatocyte growth factor and the 5 amino acids-deleted caninehepatocyte growth factor are useful for the treatment of liver diseases,kidney diseases,lung diseases, digestive diseases, cardiocirculatory diseases or cranial nervediseases.
