STROP PAVEL,DELARIA KATHERINE ANNE,DORYWALSKA MAGDALENA,FOLETTI DAVIDE LUCIANO,DUSHIN RUSSELL GEORGE,SHELTON DAVID LOUIS,RAJPAL ARVIND
申请号：
IN201617036582
公开号：
IN201617036582A
申请日:
2016.10.25
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
The present invention provides transglutaminase mediated antibody drug conjugates with high antibody drug ratio (DAR) comprising 1) glutamine containing tags endogenous glutamines and/or endogenous glutamines made reactive by antibody engineering or an engineered transglutaminase (e.g. with altered substrate specifity) and 2) amine donor agents comprising amine donor units linkers and agent moieties wherein the DAR is at least about 5. The invention also provides methods of making and methods of using such higher drug loaded antibody drug conjugates.
