Composition (I) comprises: at least one conditioned cell culture medium and/or its extract； and at least one agent that has an irritant side effect on skin, where the medium is obtainable by contacting at least one culture of digestive tract cells and at least one probiotic microorganism. An independent claim is included for a method for the treatment of signs of inflammation and/or of immune disorders, or treatment of signs of irritation of the skin and/or of the scalp, or for protecting skin cells against damage caused by UV radiation, or for protecting cells against damage to their DNA, comprising applying the conditioned cell culture medium and/or its extract to the skin and/or the scalp of a person. ACTIVITY : Antiinflammatory； Immunomodulator； Antipruritic； Dermatological； Antipsoriatic； Antiallergic； Antiseborrheic； Germatological； Muscular-Gen.； Immunosuppressive； Cytostatic. MECHANISM OF ACTION : None given.
