WENDT DANIEL J,AOYAGI-SCHARBER MIKA,LONG SHINONG,VELLARD MICHEL CLAUDE,CASTILLO SIANNA,OKHAMAFE AUGUSTUS O,PRICE CHRISTOPHER P
申请号:
ZA201107087
公开号:
ZA201107087B
申请日:
2011.09.28
申请国别(地区):
ZA
年份:
2012
代理人:
摘要:
The present disclosure provides variants of C-type natriuretic peptide (CNP), pharmaceutical compositions comprising CNP variants, and methods of making CNP variants. The CNP variants are useful as therapeutic agents for the treatment of diseases responsive to CNP, including but not limited to bone-related disorders, such as skeletal dysplasias (e.g., achondroplasia), and vascular smooth muscle disorders (e.g., restenosis and arteriosclerosis).