LIU, JUN,刘俊,劉俊,SHIRE, STEVEN J.,史蒂芬Ｊ 薛尔,史蒂芬Ｊ 薛爾,史蒂芬J 薛尔,史蒂芬J 薛爾
申请号：
TW093109166
公开号：
TWI357820B
申请日:
2004.04.02
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
The present application relates to highly concentrated antibody and protein formulations with reduced viscosity that are stable, relatively isotonic and are of low turbidity. The formulations are particularly suitable for subcutaneous administration. The application further describes articles of manufacture containing such formulations and methods for using them to treat disorders treatable by the formulated antibody or protein. The formulations comprise arginine-HCl, histidine and polysorbate.本申請案係關於具有降低黏度之高度濃縮抗體與蛋白質調配物，其係為安定、相對較等滲性且具有低混濁度。此等調配物係特別適合皮下投藥。本申請案進一步描述含有此種調配物之製造物件，及使用彼等以治療可藉由經調配抗體或蛋白質治療之病症之方法。
