Institut Pasteur de Lille;Institut National de la Santé et de la Recherche Médicale (INSERM)
发明人:
Anne-Sophie Debrie,Dominique Raze,Camille Locht
申请号：
US16848793
公开号：
US20200297833A1
申请日:
2020.04.14
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A Fim3-producing BPZE1 derivative with sufficiently stable fim3 expression to provide improved protection in mice against Fim3-only producing clinical B. pertussis isolates was developed. The fim3 expression in BPZElf3 did not alter the protective efficacy against Fim2+ strains, nor against strains that produce neither Fim2 nor Fim3.
